β-Asarone increases doxorubicin sensitivity by suppressing NF-κB signaling and abolishes doxorubicin-induced enrichment of stem-like population by destabilizing Bmi1
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منابع مشابه
Doxorubicin-induced apoptosis in H9c2 cardiomyocytes by NF-κB dependent PUMA upregulation.
OBJECTIVE The cardiotoxicity of doxorubicin limits its clinical use in the treatment of a variety of solid tumors and malignant hematologic disease. Although the mechanism by which it causes cardiac injury is not yet known, apoptosis has been regarded as one of mechanisms underlying the cardiotoxic effects of doxorubicin. In the present study, we investigates the mechanisms of doxorubicin-induc...
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background: multi-drug resistance (mdr) is a controversial issue in traditional chemotherapy of aggressive cancers, including hepatocellular carcinoma. the major cause of mdr is suggested to be the aberrant activation of the main signaling pathways such as wnt and nuclear factor kappa-light-chain-enhancer of activated b cells (nf- κb) which have key roles in the maintenance of cancer stem cells...
متن کاملDalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway
We investigated the effect of Dalbergioidin (DAL), a well-known natural product extracted from Uraria crinita, on doxorubicin- (DXR-) induced renal fibrosis in mice. The mice were pretreated for 7 days with DAL followed by a single injection of DXR (10 mg/kg) via the tail vein. Renal function was analyzed 5 weeks after DXR treatment. DXR caused nephrotoxicity. The symptoms of nephrotic syndrome...
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BACKGROUND/AIMS To define the effect of statins on interleukin 1β (IL-1β)-induced osteoclastogenesis and elucidate the underlying mechanisms. METHODS Bone marrow cells were obtained from 5-week-old male ICR (Institute for Cancer Research) mice, and they were cultured to differentiate them into osteoclasts with macrophage colony-stimulating factor and the receptor activator of nuclear factor (...
متن کاملPapaverine inhibits lipopolysaccharide-induced microglial activation by suppressing NF-κB signaling pathway
OBJECTIVE To investigate the effects of papaverine (PAP) on lipopolysaccharide (LPS)-induced microglial activation and its possible mechanisms. MATERIALS AND METHODS BV2 microglial cells were first pretreated with PAP (0, 0.4, 2, 10, and 50 μg/mL) and then received LPS stimulation. Transcription and production of proinflammatory factors (IL1β, TNFα, iNOS, and COX-2) were used to evaluate micr...
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ژورنال
عنوان ژورنال: Cancer Cell International
سال: 2019
ISSN: 1475-2867
DOI: 10.1186/s12935-019-0873-3